Despite considerable efforts to prevent pressure ulcers, data on prevalence are unacceptably high.
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Pressure ulcers are areas of soft tissue breakdown that result from sustained mechanical loading of the skin and underlying tissues they can affect the quality of life of many individuals. The etiology of pressure ulcers: skin deep or muscle bound? Arch Phys Med Rehabil 2003 84:616-9. Keeping these points in view, this article reviews the current status of decellularized scaffolds for stem cells, with particular focus on: (a) concept and various methods of decellularization (b) interaction of stem cells with decellularized scaffolds (c) current recellularization strategies, with associated challenges and (iv) applications of the decellularized scaffolds in stem cell-driven tissue engineering and regenerative medicine.īouten CV, Oomens CW, Baaijens FP, Bader DL. The ability to harness the regenerative potential of stem cells via decellularized ECM-based scaffolds has promising implications for tissue-regenerative medicine. Stem cells interact with, and respond to, various signals/cues emanating from their ECM. Despite the proven potential of decellularized scaffolds in tissue engineering, the molecular mechanism responsible for stem cell interactions with decellularized scaffolds is still unclear.
In fact, decellularized stem cell matrix (DSCM) has also emerged as a potent biological scaffold for controlling stem cell fate and function during tissue organization. In recent years, donor organs, such as heart, liver, lung and kidneys, have been reported to provide acellular extracellular matrix (ECM)-based scaffolds through the process called 'decellularization' and proved to show the potential of recellularization with selected cell populations, particularly with stem cells. The potential of decellularized scaffolds, derived from native tissues or organs in the form of scaffolds has been evolved as a promising approach in tissue-regenerative medicine for translating functional organ replacements.
However, a dearth of available donor organs for transplantation leads to the death of numerous patients waiting for a suitable organ donor.
Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions.
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